Coronavirus and Covid-19 Rumination #5

By Rud Istvan – Re-Blogged From WUWT

The world continues to learn about this sometimes deadly new zoonotic virus. We know now from NYC that it is disproportionately serious in males (61% of tested symptomatics), more fatal in people over 65 (63%), and is disproportionately lethal (84%) in people with especially the comorbidities hypertension (55%), diabetes (35%) and obesity (50% of serious/critical [s/c] hospital admissions in NOLA, under 60 years old 2x s/c in NYC). More on the significance of these facts is developed below.

We know from two inadvertent extreme ‘lack of social distancing’ “experiments”, Diamond Princess (DP) and CVN71 (Theodore Roosevelt, TR), that only about 15% (TR) to 19% (DP, with several more weeks of exposure) ever test positive for the virus. That means that something like 80-85% of people have an immune system that seems to handle the virus effortlessly even in highly infectious, high viral titer circumstances–so that not even a positive viral shedding test develops. This could just be a very good innate immune system; it could also be a primed active immune system (i.e. the population was NOT naïve). A very plausible explanation hypothesis is developed below with important ramifications for opening countries from extreme lockdown measures.

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Diabetic Mice “Cured Rapidly” Using Human Stem Cells

By Victor Tangermann – Re-Blogged From Futurism

These insulin-secreting cells cured mice from severe diabetes “within two weeks.”

A team of researchers at the Washington University School of Medicine in St. Louis successfully converted human stem cells into cells capable of producing insulin. These insulin-producing cells were then able to control blood sugar levels in a demonstration involving diabetic mice.

“These mice had very severe diabetes with blood sugar readings of more than 500 milligrams per deciliter of blood — levels that could be fatal for a person — and when we gave the mice the insulin-secreting cells, within two weeks their blood glucose levels had returned to normal and stayed that way for many months,” lead researcher Jeffrey Millman, assistant professor at Washington University, said in a statement.

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Drug Combination Grows Cells to Control Diabetes

By Health Day – Re-Blogged From Newsmax Health

People with diabetes often don’t have enough insulin-producing beta cells to control their blood sugar, but a combination of two novel drugs may coax the body into making more of these vital cells, an early study finds.

Together, the drugs caused beta cells to reproduce at a rate of about 5 percent to 8 percent a day, according to the researchers. Work has only been done in the lab and in rodents, and a major hurdle remains before this treatment could be tried in humans: researchers need to develop a targeted delivery system.

“We’re at a stage where we have nuclear warheads but no guided missiles. We can’t just release the treatment because we don’t want to affect other cells,” explained study senior author Dr. Andrew Stewart. He’s the director of the Mount Sinai Diabetes, Obesity and Metabolism Institute in New York City.

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Government Dietary Guidelines are Plain Wrong: Avoid Carbs, Not Fat

By Sarah Hallberg – Re-Blogged From The Hill

America is facing a chronic disease crisis. The federal government is fueling that crisis by promoting flawed nutritional advice that contradicts the latest research.

Every five years, the Departments of Agriculture and Health and Human Services publish the “Dietary Guidelines for Americans,” which detail which foods Americans should eat or avoid. The highly influential document directs food labeling, school menus, public food programs, and government research grants.

Researchers claim the guidelines are based on “the preponderance of current scientific and medical knowledge.” Yet, since they were first introduced back in 1980, they’ve barely changed, even though a recent revolution in nutritional science has cast doubt on old assumptions.

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Millions Left Behind as Diabetes Drives Surge in Insulin Demand

[In the 1960s, my dad’s pharmacy sold insulin for about $2.50 a vial. Today the price is 20 times as much, while the general price level has gone up ‘only’ 10+ times. I expect the price rise disparity is due largely to regulation and to mostly government 3rd party payers like medicaid. -Bob]

By Thomson Reuters – Re-Blogged From Newsmax Health

A global diabetes epidemic is fuelling record demand for insulin but tens of millions will not get the injections they need unless there is a dramatic improvement in access and affordability, a new study concluded on Wednesday.

Diabetes — which can lead to blindness, kidney failure, heart problems, neuropathic pain and amputations — now affects 9 percent of all adults worldwide, up from 5 percent in 1980.

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Experimental Drug Halts Parkinson’s Progression

By Clyde Hughes – Re-Blogged From Newsmax Health

An experimental drug developed by Johns Hopkins University researchers appears to slow down the progression of Parkinson’s disease and its symptoms in mice, a statement from the university said this week.

The researchers said that the drug called NLY01 has been proven in studies to block the degradation of brain cells that is the leading cause of Parkinson’s disease. The treatment has been used in the past to treat diabetes, researchers said in the university statement.

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Life-Extending Discovery Renews Debate Over Aging as a ‘Disease’

By – Re-Blogged From Seeker

Even if a new drug proves to prolong human life, it won’t receive regulatory approval for that purpose unless the FDA accepts that aging is a treatable medical condition.

“We’re not going to see people spend longer in nursing homes. We’re going to see them spend more time out of nursing homes.”

“I think this is probably the most exciting thing to happen in aging research yet, and I think that’s going to be true no matter how the trial results turn out.”

How Much Water Do You Really Need?

Re-Blogged From Newsmax Health

During the summer — and even year-round — our bodies crave water. There’s no way to live without it. But just how much do we really need every day to stay healthy?

The answer can get complicated.

“It’s hard to find an exact amount because it’s variable based on your age, where you live, whether it’s hot and humid, or cold and dry. Are you male or female, more active or less active,” said Ilyse Schapiro, a registered dietitian with nutrition counseling practices in New York and Connecticut.

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Brain Stimulation Could Ease Diabetes Symptoms

By David Alliot – Re-Blogged From Newsmax Health

The premise is clear: Find a way to increase dopamine (a chemical released by nerve cells to stimulate pleasure) and the body’s natural ability to process sugar is increased — key to helping people with diabetes. This mode of regulating sugar control is well-known in mice, but thanks to new research that led to human trials, the same appears to be true for humans.

A Weight-Loss Injection? Human Trial Successful

By Clyde Hughes – Re-Blogged From Newsmax Health

A weight loss injection that mimics gastric bypass surgery was proven effective in a human trial conducted by scientists at London’s Imperial College. It’s being called “the most exciting” advance ever in treating obesity.

The researchers said patients participating in the trial ate about 30 percent less food after being treated with the hormone injection, The Telegraph reported, and in some cases patients were able to ditch their diabetes medication because of the resulting weight loss.

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7 Health Myths You Should Not Believe Anymore

By Romit Malhotra

(Summary:

Vitamin C doesn’t protect from cold, diabetes doesn’t affect elders only, and your microwave doesn’t destroy the nutrients. And so many more health myths you should not believe anymore.)

Do you believe that carrots improve vision? Does an apple a day keep the doctor away? Or you fear that microwave can kill the nutrients in your food?

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Life-Extending Discovery Renews Debate Over Aging as a ‘Disease’

By – Re-Blogged From Seeker

Even if a new drug proves to prolong human life, it won’t receive regulatory approval for that purpose unless the FDA accepts that aging is a treatable medical condition.

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